Physiological antioxidant system and oxidative stress in stomach cancer patients with normal renal and hepatic function

Role of free radicals has been proposed in the pathogenesis of many diseases. Gastric cancer is a common disease worldwide, and leading cause of cancer death in India. Severe oxidative stress produces reactive oxygen species (ROS) and induces uncontrolled lipid peroxidation. Albumin, uric acid (UA) and Bilirubin are important physiological antioxidants. We aimed to evaluate and assess the role of oxidative stress (OS) and physiological antioxidant system in stomach cancer patients. Lipid peroxidation measured as plasma Thio Barbituric Acid Reactive substances (TBARS), was found to be elevated significantly (p=0.001) in stomach cancer compared to controls along with a decrease in plasma physiological antioxidant system. The documented results were due to increased lipid peroxidation and involvement of physiological antioxidants in scavenging free radicals but not because of impaired hepatic and renal functions

Design and Development of an Airblast Atomiser for the KAVERI engine and the sectoral combustor tests

This report deals with the design and development of an airblast atomiser for application in the KAVERI engine. Five atomisers of the chosen design were fabricated and tested at ambient conditions to determine the fuel spray SMD, patternation, cone angle and atomiser flow number. The atomiser performance parameters specified were achieved and hot tests carried out in the 90° combustor sector. The combustor pressure loss, exit temperature distribution, ignition and stability limits were evaluate

Recent developments in life sciences research: Role of bioinformatics

Life sciences research and development has opened up new challenges and opportunities for bioinformatics. The contribution of bioinformatics advances made possible the mapping of the entire human genome and genomes of many other organisms in just over a decade. These discoveries, along with current efforts to determine gene and protein functions, have improved our ability to understand the root causes of human, animal and plant diseases and find new cures. Furthermore, many future Bioinformatic innovations will likely be spurred by the data and analysis demands of the life sciences. This review briefly describes the role of bioinformatics in biotechnology, drug discovery, biomarkerdiscovery, biological databases, bioinformatic tools, bioinformatic tasks and its application in life sciences research

Role of atmospheric stability over the Arabian Sea and the unprecedented failure of monsoon 2002

The anomalous behaviour of the monsoon 2002 has been studied. We have made an attempt to combine satellite and other data sources to characterize the thermal stratification over the Arabian Sea during different phases of monsoon 2002. Using NOAA-ATOVSderived atmospheric temperature and moisture profiles, we have calculated a daily stability index (SI) over the entire Indian region and surrounding oceans. The time series of SI clearly brings out the three major significant epochs of monsoon 2002. The relatively dry atmosphere west of 65° E, signifying lack of convection and an unstable atmosphere over the southeast Arabian Sea with west-to-east gradients in water vapour, SI and cloud liquid water content are noted. The unfavourable stratification during July over the entire Arabian Sea has been investigated in detail. The dominant modes of instability oscillations have been seen to be ~ 30 days both over the western and eastern Arabian Sea, while for the high-frequency modes preference was seen over the eastern part. Using the analysed fields of the National Centre for Medium Range Weather Forecasts, the relative contributions of advective and subsidence components in the maintenance of stratification have been investigated. The latter has been found to have played a more dominant role in the deficit monsoon 200

Mol-CycleGAN - a generative model for molecular optimization

Designing a molecule with desired properties is one of the biggest challenges in drug development, as it requires optimization of chemical compound structures with respect to many complex properties. To augment the compound design process we introduce Mol-CycleGAN - a CycleGAN-based model that generates optimized compounds with high structural similarity to the original ones. Namely, given a molecule our model generates a structurally similar one with an optimized value of the considered property. We evaluate the performance of the model on selected optimization objectives related to structural properties (presence of halogen groups, number of aromatic rings) and to a physicochemical property (penalized logP). In the task of optimization of penalized logP of drug-like molecules our model significantly outperforms previous results

Hummingbird: An Energy-Efficient GPS Receiver for Small Satellites

Global positioning system (GPS) is the most widely adopted localization technique for satellites in low earth orbits (LEOs). To enable many state-of-the-art applications on satellites, the exact position of the satellites is necessary. With the increasing demand for small satellites, the need for a low-power GPS for satellites is also increasing. However, building low-power GPS receivers for small satellites poses significant challenges, mainly due to the high speeds (similar to 7.8 km/s) of satellites and low available energy. While duty cycling the receiver is a possible solution, the high relative Doppler shift among the GPS satellites and the small satellite contributes to an increase in Time to First Fix (TTFF), which negatively impacts energy consumption. Further, if the satellite tumbles, the GPS receiver may not be able to receive signals properly from the GPS satellites, thus leading to an even longer TTFF. In the worst case, the situation may result in no GPS fix due to disorientation of the receiver antenna. In this work, we elucidate the design of a low-cost, low-power GPS receiver for small satellites. We also propose an energy optimization algorithm to improve the TTFF. With the extensive evaluation of our GPS receiver on an operational nanosatellite, we show that up to 96.16% of energy savings can be achieved using our algorithm without significantly compromising (similar to 10 m) the positioning accuracy

Antibacterial studies and phytochemical constituents of South Indian Phyllanthus species

Antibacterial activity and phytochemical tests of the methanol extracts of six Phyllanthus species were evaluated. In agar well diffusion assay the diameter of inhibition zones ranged from 3 - 22 mm. Phyllanthus amarus showed maximum activity of 22 mm. The minimum inhibition concentration (MIC)and minimum bactericidal concentration (MBC) observed for Bacillus stearothermophilus, Staphylococcus aureus, Bacillus subtilis, Micrococcus leuteus, Salmonella typhi, Enterobacter aerogens, Proteus mirabilis, and Proteus vulgaris were 30 - 205 ìg/ml and 40 - 230 ìg/ml, respectively.P. amarus, P. hookeri and P. maderaspatensis showed the lowest MIC (30 ìg/ml) as well as MBC (40 ìg/ml) and thus an effective inhibitor of the tested bacteria. Lignans, triterpenoids and phenols were detected in all the 6 tested plants